Groundwater simulation and application of karst water-bearing medium are hot spots and difficulties in hydrogeological work. In this research,Jingguan area in the east wing of the Guanyinxia anticline was selected as the research object, and the multiple pumping test data of 3 geothermal wells were obtained. Based on Visual Modflow software platform, the numerical simulation model was established,and interwell interference degree of the geothermal well with the exexisting UK1in different conditions was calculated. The results show that:when the distance between a new drill and ZK1 and its mining amount is 1 km and 500 m³/d, 2 km and 1 000 m³/d, 5 km and 1 500 m³/d, 2 000 m³/d and 2 500 m³/d, respectively, there is no effect on the flow field near the ZK1;when the distance between a new drill and ZK1 and its mining amount is 1 km and 1 000 m³/d, 2 km and 1 500 m³/d, 5 km and 3 000 m³/d,the water head of ZK1 well decreases by 19 m, 13 m and 8 m respectively, illustrating that the smaller the spacing of geothermal wells and the larger the mining volume, the greater the probability of interference with adjacent wells. It proves feasible to simulate the characteristics of geothermal flow field using the Visual Modflow model.