We built a fluid network model of human blood circulation with lymphatic system based on fluid network dynamics and circuit graph theory, and used first 10 harmonios waves to simulate the blood flow equation. In hemodynamics respect, the effect of lymph branch on systemic circulation and mutual influences of every branch were simulated by changing the branches resistance in the model. Hemodynamics parameters were obtained by average method of adaptive control, and the biophysical effect of the lymphatic system on microcirculation was discussed. The results show that, when lymphatic microcirculation has a disorder, and lymph branch flow resistance ratio is η=3, the average flow of this branch is decreased by 42.24%, and the relative decrease in the awerage flow of other branches in not more than 0.04%. The changes in the flow resistance of other branches will lead to a decrease by at least 2.69% of the lymphatic branch flow. This study provides reference for analysis of microcirculation disorder and the relation between systemic circulation and microcirculation.