High-rise building structure design is not only a specialized and practical course， but also a very important core course in the branch of architectural engineering of civil engineering. Logicality and high practice are characteristics of the course．In the teaching process， the urgent problem to be solved is how to arouse students’ interest in learning high-rise building structure design．Based on the teaching practice of high-rise building structure design, the existing problem in the teaching content is summarized, some meaningful exploration on teaching method is carried out, and some suggestion for the teaching reform of the course is proposed. Through the practice results, the teaching effect is good.