During six years of practice teaching reform and practice， the department of Engineering Management of Chongqing University has explored new ways of practice teaching for liberal arts students of higher education to complete graduation design. Through multi-specialty coordination graduation, it aims to cultivate engineering management professional talents with comprehensive quality and practical ability.This thesis explores the practical teaching mode of engineering management multi-specialty coordination graduation design in Chongqing University, and expounds the basically objective law of teaching of graduation design, the collection of graduation design topic and operation mechanism of multi-specialty design, security and management style. It provides a new train of thought to cultivate more engineering management professionals with knowledge integration,coordination ability and comprehensive quality.