The university-enterprise cooperation training mode for professional degree postgraduates aims to cultivate high-level application-oriented talents. Taking Wuhan University of Technology as an example, we summarized the experience and practice of university-enterprise cooperation training mode based on the practice of training full-time professional degree postgraduates in the field of architecture and civil engineering, including the construction of teachers, training mode reform, curriculum construction, practice teaching, training base construction, training process monitoring and quality evaluation. The results will promote the change and innovation in the training mode of full-time professional degree postgraduates.