The trend of web assistant teaching is becoming inevitable along with the rapid development and popularization of computer network technology and terminal equipment. However, it exposed some problems in the procession of teaching website construction such as the assistant role of teaching websites are not realized definitely, the content of the websites are not matched with the class teaching, and the website are too complicated to construct and maintain. Based on the discussion of the positioning and the construction target of the specialized core course teaching website in university, this paper set up a mode laided teaching website for science and engineering professional basic course combined with the teaching practice of architectural mechanics in Guangzhou University. The content of the website covers basic courses information, teaching resources sharing, expand resource promoting and teaching forum. Especially, the construction of teaching forum opened up an on-line interactive platform for teachers and students, which can solve the incompatibility between the office hours of teachers and the after-class study time efficiently. Actually, the question answering of the teacher and the discussion between students have very important positive significance in arousing learning interest, promoting deeper understanding of related mechanical problems, and eventually, improving the quality of teaching. The established architectural mechanics website are applied in assistant teaching in Guangzhou University and obtained significant achievement.