As a superior feature major in provincial university, building environment and energy engineering in Zhongyuan University of Technology needs transition under the new situation, i.e., social structure transformation and upgrading, innovation and entrepreneurship driven development. In this paper, based on responding to the construction of Central China Economic Zone and the need of regional economic development, an exploring on comprehensive reform for building environment and energy engineering was proposed from the following aspects, such as talent training plan, teaching team, curriculum and teaching resource, teaching methods, practical and innovative ability and teaching management, etc., which aimed to build a new major system combined with regional industry and innovation chain, and realize the transition of talent-training model and promote the core competitiveness of the major.