Aiming at the disadvantages of the current cultivation about the practice and innovation ability of master of engineering management(MEM) graduate students, this paper proposes an opinion though building a university and enterprises co cultivation mode with the stable and long-term characteristics systematically to improve the practice and innovation ability of MEM graduate students, and puts forward a university and enterprises co cultivation mode framework, analyzes the implementation focuses of this cultivation mode,then introduces the effect of this mode through a specific case in order to provide reference to MEM postgraduate training institutions to enhance the practice and innovation ability of MEM graduate students.