Under the background of the new era, technological innovation has become the core competitiveness of enterprises, and talents have gradually become the main driving force for enterprises to maintain competitiveness. After analyzing the lack of matching between college education and enterprise employment demand, taking the market as the guidance and combining with the characteristics of the school, this paper explores the connotation of personal training under the mode of school-enterprise cooperation and puts forward a new training mode of graduation design. Some concepts and methods like "actual combat", "one-in and one-out", "centralization and dispersion", "stereoscopic review", and "double tutorial system" are put forward. In view of the problems and challenges encountered in practice, some discussions and suggestions are put forward on the establishment and operation of the long-term mechanism of school-enterprise cooperation.