The course of seismic design of engineering is a core course of civil engineering. By analyzing the characteristics and problems in the course teaching, and by a questionnaire survey of students, we can deeply understand the students' mastery of this course and explore the teaching reform of the course combing with its actual situation. Subject modular teaching is adopted to clarify the learning topics of each module, and the knowledge points of different modules are explained in detail to promote the rapid and high-quality absorption of students. With the help of modern new teaching methods, online and offline learning is carried out, the contents of other professional courses are infiltrated, and the latest norms are integrated. At the same time, engineering cases allow students to understand the importance of seismic design, and combination of theory with practice is emphasized, classic cases are analyzed, deeply researched and connected with textbook knowledge, to diverge students' thinking. It provides students with multi-angle knowledge vision and uses BIM numerical simulation to teach. Through students' participating in the national college student structure design competition, combining with seismic knowledge points, students can master the knowledge of basic theory and understand the latest frontier technology and related theories of the earthquake-resistant industry. Students have a strong interest in learning, answer questions and discuss actively in class, so that they can deeply understand the knowledge points of each chapter and the teaching effect is good, and it can provide certain references for application-oriented undergraduate colleges.