Major public emergencies are closely related and connected with the construction of the grassroots organizations of the Communist Party of China. Major public emergencies are a test for the construction of the grassroots Party organizations, and the grassroots Party organizations as the main body involved in handling the incident should be firm in "four self-confidences" and "two maintenances" to meet the difficulties and continuously improve the level of organization construction. The grassroots Party organizations must take precautions in the process of responding to major public emergencies and make emergency contingency plans, strengthen the foundation and strengthen the credibility of the grassroots Party organizations, dare to act and play the exemplary role of Party members as pioneers, be double-pronged and focus on spirit and material security. In practice, we should improve the capacity and construction level of grassroots Party organizations and win the victory in handling major public emergencies.