The moral education practice base, as an important carrier of college moral education, shoulders an important mission in the process of talent training in colleges and universities. This article intends to focus on the new requirements in the new era to solve the problem of fragmentation and randomization of the second classroom practice class in schools, eliminate the dilemma of lack of synergy and waste of resources in the construction of the moral education practice base, and explore the construction of "3-1-1"mode under the harmonious perspective, through the construction of an innovation platform, restructuring the teaching staff, starting database construction, improving the effectiveness of the construction of the second classroom moral education practice base in colleges and universities, and enhancing the scientific and long-term effectiveness of the practice base system.