Intelligent manufacturing is the main trend in manufacturing today, and talent is the primary resource. Colleges and universities, as the origin of export of a large number of talents, face huge challenges. Aiming at the problems of engineering application ability cultivation of domestic college mechanical engineering students, this paper proposes new requirements for the talents of mechanical engineering professionals in the context of intelligent manufacturing based on the training objectives and the corporate social needs analysis. Based on the analysis of the status quo of the training of mechanical engineering professionals in some local undergraduate colleges, a new multidisciplinary cross-integration training model suitable for mechanical engineering professionals is proposed. Compared with the traditional interdisciplinary teaching program, the new multidisciplinary cross-integration training model has obvious universality. It can provide suggestions for cultivating high-quality intelligent manufacturing application talents that meet the requirements of enterprises.