The course construction of earthquake resistance and disaster prevention of engineering structure is very important to cultivate comprehensive talents with both ability and morality in the field of disaster prevention and mitigation. To fulfill the basic task of cultivating talents with moral integrity, enrich teaching materials and teaching methods, improve the activity of classroom, and guarantee the teaching quality, combined with professional interpretation and discussion of typical engineering damage, an infiltrative ideological and political teaching mode of the course has been established. The bilingual interactive teaching practice of the course has been implemented through teaching and thematic instruction by international famous experts. The students' understanding on the knowledge of earthquake resistance and disaster prevention of engineering structures has been promoted by strengthening the practical teaching of the course. The teaching resources sharing platform of the course has been established to share the high-quality teaching resources in time. Meanwhile, the teaching strategy of the course in epidemic period is explored and verified, which can provide reference for the course teaching of earthquake resistance and disaster prevention of engineering structures in the period of major epidemic.