Practice education is an important part of the work of teaching and education in colleges and universities in the new era, is an important link in the high-quality education system, and is an effective measure to carry out the fundamental task of setting up morality and cultivating people. This paper analyzes the connotation of the new era of practice education in colleges and universities, expounds the core status and value of practice education in the talents training, and clarifies the need to inherit the philosophical wisdom of practice education in colleges and universities in the new era. At present, there are some realistic circumstances in the process of practice education, such as unclear target orientation, insufficient attention, imperfect mechanism and system, single content and form, etc. Therefore, colleges and universities need to constantly innovate talent training mode, strictly follow the educational law of talent training, rely on practice to carry out ideological and political education, and fully develop quality education, to enhance students’ comprehensive ability effectively. In the light of the above problems, this paper puts forward the important proposition that colleges and universities should focus on cultivating contemporary talents who are responsible for the great task of national rejuvenation, take the educational policy of Party as the leadership, and scientifically do the top-level design of practice and education, to construct a multi-dimensional coordinated education mechanism, to establish and improve the quality assurance system and long-term mechanism of practice education, and to promote the high-quality and good-frequency resonance between practice education and the connotation development of colleges and universities, according to the law of students’ growth, we should construct the scientific matrix of practice education in content and form, establish a high-quality and characteristic practice education system, and provide students with abundant practice projects, to train contemporary talents with the all-round development of moral, intellectual, physical and aesthetic labor, who can be a major task of national rejuvenation.