Educational informatization 2.0 emphasizes the deep integration of education and information technology. To improve the quality of talent training, the innovative teaching and learning needs to be highlighted. Based on the new educational ecology of "Internet + education", this paper presents the basic concepts, advantages and characteristics of SPOC and blended teaching. The theoretical basis of the mixed teaching mode is discussed. A blended teaching mode based on SPOC is developed, including three parts, namely, teaching preparation, teaching process design and assessment design. The results show that the mixed teaching mode on the basis of SPOC strengthens the dominant position of students’ learning, which also improves learning depth, and achieves the training objectives such as practical application,decision-making analysis,critical thinking. At the same time, through teaching reflection, we deeply realize that the mixed teaching mode puts forward more challenged requirements for the educators’ teaching and learning ability.The participation of universities, research institutes and teachers and students can promote the practice of SPOC teaching reform.