To meet the demand of the development of building industrialization, a series of reforms in the graduation design of building construction orientation for civil engineering specialty are carried out in South China University of Technology, which includes the adjustment on the graduation design objectives, topics, design content, implementation means, schedule, results submitted, etc. To ensure the smooth implementation of the reform, some effective measures are taken. For example, the implementation path of the reform is formulated by using PDCA cycle, so that the graduation design practice can be continuously improved year by year. The design of prefabricated concrete structure, BIM-based deepening design of prefabricated components, collision analysis, construction process simulation, measurement and pricing are introduced, making the traditional state of taking the structural design of cast-in-place concrete frame as a single design content changed. Through multi-dimensional university-enterprise cooperation, online and offline guidance mode and excellent student teaching assistants, the problems of lack of teachers and software application in the field of prefabricated structure design are solved. Facilitated by the combination of competition and teaching, the teaching quality is promoted, and students’ ability is measured. Issues such as the choice between the traditional manual calculation content and the computer calculation content, the setting of the design content of the cast-in-place components and prefabricated components, the balance on design difficulty and workload, are discussed. The design task and schedule are suggested to be arranged based on the measurement results, and for students with different ability levels, the required and optional content can be set to meet their development needs. After the reform, the overall workload and difficulty of the graduation design are increased, and the design content is more in line with the engineering practice. Students’ software application skills are greatly improved, and their understanding in detailed structure, production and construction process of prefabricated components is deepened. The reform has achieved good effect, providing a good basis and reference for the development of intelligent construction specialty.