The fourth industrial revolution characterized by digitalization，networking and intelligence is profoundly affecting China’s higher engineering education system，and cultivating high-level international engineering cost talents is an important support for the construction industry to promote intelligent construction and move towards the global high-end value chain.With the reform of the national economic system and the adjustment of the industrial structure， the cost management of construction project has moved from the partial management of takeoff and pricing to the information control of the whole life cycle of the building，and the knowledge structure system of engineering cost major has also moved from single to multidisciplinary knowledge.Taking the change of industrial structure as the logical main line，this paper divides the evolution and development of China’s engineering cost major undergraduate professional knowledge structure into four stages，discusses the characteristics of engineering cost undergraduate professional knowledge structure at each stage and summarizes the experience，and makes suggestions for improving the quality of high-quality composite engineering cost professionals who cultivate multidisciplinary cross-knowledge．