As an important professional foundation course of most engineering majors, mechanics of material aims to train students to master solid basic mechanics knowledge, and have practical ability to integrate basic mechanics knowledge with engineering problems. At the present stage, a new round of scientific and technological revolution and industrial transformation is flourishing. Higher requirements are put forward for high quality creative talents with solid mechanics knowledge. However, some problems are still common, such as unattractive traditional classroom teaching, lack of interest in learning, and lack of ability to analyze and solve problems. Therefore, it gets great significance to carry out teaching reform and exploration of mechanics of material. Under the background of curriculum system reform which is aiming at engineering education certification and concept of OBE, the knowledge module of mechanics of material is regrouped, and practical problems and engineering cases are introduced into the teaching process. The new teaching mode is explored. A variety of teaching methods are used, and the students’interest in learning have been increased. Students gradually become the main body of learning, and the purpose of cultivating innovative talents with creative consciousness and practical ability can be achieved.