Civil engineering is a discipline that combines theory with practice. Facing the needs of industrial upgrading and technological developing, collaborating with enterprises to strengthen the cultivation of students’ engineering practical abilities is an inevitable choice for the cultivation of civil engineering talents under the background of industry-education integration. Taking the course of asphalt and asphalt mixtures as an example, the reform measures of industry-education integrated courses from the aspects of curriculum syllabus revision, teaching content optimization, teaching method design, and evaluation method innovation are explored. In terms of teaching content, the professional course contents that integrate industry-university-research institution-innovation have been constructed through synchronous updates of course contents with industry development, close integration of practical contents with professional knowledge, and effective transformation of industry-university research projects and engineering cases. As for teaching methods, an integrated teaching innovation model of learning, doing, and creating has been established, which enhances students’ ability and literacy to analyze and solve complex problems from three aspects: knowledge learning, skill training, and entrepreneurial ability. In terms of course assessment, a three-level practical ability assessment system has been developed, strengthening the evaluation of practical processes and abilities. The achievements can provide reference for the reform of other courses.