As an important part of professional comprehensive teaching, the graduation design of civil engineering major has a positive impact on improving college students’ professional comprehensive ability, engineering awareness, engineering design ability, innovation ability and teamwork spirit. It has long been one of the key points of teaching reform in colleges and universities. In view of the Overall Plan for Promoting the Construction of World-class Universities and Disciplines put forward in 2015, and based on the general background of the construction of first-class disciplines, given that civil engineering graduation design topics are outdated, the content is single, the design and expression lags behind the development of the times, the process management is unscientific, the students pay insufficient attention, the instructors lack engineering experience, and the software teaching is underdeveloped, School of Civil Engineering of Xi’an University of Architecture and Technology has successively carried out several teaching seminars on graduation design, and systematically formulated the teaching reform plan. Field research in Tongji University, Nanjing Tech University, Southeast University, Beijing Jiaotong University, Beijing University of Technology and other schools with strong strength in the field of civil engineering in China from 2019 to 2020 was conducted to learn the teaching concept and advanced experience in graduation design of civil engineering in an all-round, multi-level and multi-dimensional way. Multi-dimensional teaching reform measures were put forward involving the whole process of the graduation design in many aspects, such as topic selection, process management, student ability, teacher level, teaching effect, and the overall process of graduation design after the teaching reform was summarized. After nearly three years’ practice, satisfactory teaching reform results have been achieved.