The course of seismic design of engineering is an important core course of civil engineering. By analyzing the characteristics and problems in teaching courses, as well as the questionnaire survey of students, we can deeply understand the students "mastery of this course and combine the actual situation of this course, the teaching reform of this course is performed. The subject modular teaching is adopted to clarify the learning topics of each module, and the knowledge points of different modules are explained in detail to promote the rapid and high-quality absorption of students. With the help of modern new teaching methods, online and offline learning is carried out, and the content of other professional courses is infiltrated and integrated with the latest norms. At the same time, the case of deep fusion engineering allows students to understand the importance of seismic design, emphasizing theoretical connection with practice, deep analysis of classic cases, in-depth research on it, and the connection with textbook knowledge, divergent student thinking. It provides students with multi-angle knowledge vision and uses BIM numerical simulation to teach. Through students participating in the National college student structure design competition, combined with seismic knowledge points, keep pace with the times, so that students can master the knowledge of basic theory and understand the latest frontier technology and related theories of the earthquake-resistant industry. Students have a strong interest in learning, answer questions in the classroom and interactive discussions, so as to deeply understand the knowledge points of each chapter. The teaching effect is good, and it has a certain reference role for application-oriented undergraduate colleges.