Intelligent manufacturing is the main trend in manufacturing today, and talent is the primary resource. Colleges and universities, as the export destinations of a large number of talents, face huge challenges. Aiming at the problem of engineering application ability cultivation of domestic college mechanical engineering students, this paper proposes new requirements for the talents of mechanical engineering professionals in the context of intelligent manufacturing based on the training objectives and the needs analysis of the corporate society. Based on the analysis of the status quo of the training of mechanical engineering professionals in some local undergraduate colleges, a new multidisciplinary cross-integration training model suitable for mechanical engineering professionals is proposed, and the teaching implementation under the new multi-disciplinary cross-fusion training model is discussed Compared with the traditional interdisciplinary teaching program, the program has obvious universality. Provides reference suggestions for cultivating high-quality intelligent manufacturing application talents that meet the requirements of enterprises.