The national virtual simulation experimental teaching center is the product of the in-depth integration of disciplines and information technology, and it is also the development direction of experimental teaching. From the perspective of global industrial development, Chinese new economic development, and the transformation of engineering education paradigm, it is responsible for the national virtual simulation experiment teaching center to promote “intelligence + education” educational productivity. The new challenges currently facing the center and the preliminary reform exploration in Fujian University of Technology are introduced. Finally, some suggestions are given for the continuous construction of the national virtual simulation experimental teaching center.