Mechanics is an important scientific foundation for engineering subjects, and the innovation experiment course of mechanics is an important carrier to deepen the understanding of mechanics theory and effectively connect engineering technology. The construction of “new engineering” urgently requires the reform of the innovation experiment teaching system for mechanics. Considering the current status and shortcomings of innovation experiment teaching of mechanics, looking into national strategic technology and industrial needs, highlighting industry characteristics, focusing on cross-disciplinary integration, a research-based experimental teaching system of “Engineering Technology Frontier-Innovation Experiment Project-Innovative Product” had been established, and the implementation scheme of the teaching system also had been proposed. Teaching practice shows that this teaching system significantly improves the awareness and ability on “Originality-Innovation-Entrepreneurship” of engineering students, and has good practical significance and promotion value.