In the reform of deepening the integration of industry and education and collaborative education, there are some problems, such as "the school is hot, the enterprise is cold". Therefore, the real estate of Chongqing University developed a "three chain cooperation" talent training system based on the triple helix theory, which systematically integrated curriculum chain, talent chain and industry chain, guided "curriculum chain" with "industry chain", matched "industry chain" with "talent chain", and connected "talent chain" with "curriculum chain". And in the process of “first-class specialty”construction, further explored and practiced the “whole process,depth,win-win”school-enterprise cooperation excellent talent training mode, and established the “four channels” for enterprises to participate in the whole process of talent training, through the participation of enterprises and industry associations in specialty construction, the joint construction of high-quality teaching platform by schools and enterprises, the introduction and sharing of high-quality resources, and the participation of enterprises in the whole process of talent training. Remarkable achievements have been made in education, and it provides a model for the integration of industry and education and the reform of school-enterprise cooperation.