In view of the problems faced in the training of graduate students majoring in architecture and civil engineering in local application-oriented universities, the research and practice of training mode were carried out. Relying on the collaborative innovation center for mountain geological disaster prevention and control in Zhejiang Province, the resource advantages, discipline advantages and scientific research advantages of the collaborative innovation center are transformed into postgraduate training advantages. The professional degree postgraduate training mode of multi-agent collaboration and integration of industry, university and research is constructed, and different training mechanisms such as university-university (or institute) collaborative training, university-enterprise collaborative training and international collaborative training are established. Taking professional foundation, practical ability and international vision as the training concept, the corresponding professional degree graduate talent training scheme and curriculum system are formulated. Practice has proved that through the cooperation of universities, scientific research institutes, enterprises and international academic organizations, together with the integration of industry, university and research, the practical innovation ability, employment competitiveness and international vision of professional degree postgraduates have been promoted.