It is the primary goal of education in universities to cultivate talents in line with the needs of society and the country. With the implementation of the national "engineering" construction project and the advocacy of the "three complete education" concept, it is particularly necessary for colleges and universities to reform the existing talent training system. Based on the investigation and analysis of practical teaching platform for whole process applied talent cultivation of civil engineering major in the University, it is to analyze the way and method of practical teaching platform for whole process applied talent cultivation under the background of engineering during period in Application-oriented Universities, which is from these terms: top level design of practice platform system, construction of cross integration comprehensive practice platform, the establishment of school enterprise cooperative education mechanism, construction of compound practical teaching team, establishment of progressive practice teaching system, in this paper. It is hoped to provide a reference for similar local colleges and universities.