Under the background of new engineering construction, the multi-level connotative education reform and practice was conducted , represented by “Air Conditioning”, which is the core course of Energy and Power Engineering in Harbin University of Commerce. The main contents of the reform include multi-dimensional interdisciplinary integration of theoretical course system, innovation and exploration improvement of practice teaching system, the construction of teaching materials and the revision of the syllabus, reform of teaching skills and examination methods. Based on depth integration of “Xi Jin-ping thought on socialism with Chinese characteristics for a new era”, construction of curriculum-based accurate ideological and political education was carried out, focusing on enhancing students' national confidence, cultural confidence, system confidence and professional quality. After three years of teaching reform and exploration, the teaching thinking and knowledge system of "Air Conditioning" has been significantly improved in terms of the innovation and characteristics of the New Era. The cultivation quality of high-quality talents has been significantly promoted for energy and power engineering major.