“Fluid Network for Transportation and Distribution” is a core course of building environment and facilities engineering. It is a technical basic course for engineering students to learn and master the basic knowledge and basic design methods in the process of various fluid transmission and distribution. Taking the opportunity of continuing to deepen the undergraduate teaching reform and connotation construction of Dalian University of Technology, and comprehensively improving the quality of talent training, the course resource platform was reformed based on the improvement effect of “Fluid Network for Transportation and Distribution” course and the lack of teaching methods. In combination with the first batch of national first-class curriculum construction experience, student centered, advocate “learning by doing while facing tasks, learning by discussing basic knowledge, and learning by analyzing engineering cases”，the interactive teaching method of combining virtual and real is proposed, and the entity platform of complex fluid network is constructed. At the same time, the corresponding simulation platform is customized, and the interactive platform of simulation, regulation and data collection of virtual and real is established. Online teaching completes the customization of data model and some simulation modules; Offline combined with the engineering test-bed, the virtual real process of self-built platform and regulation is actually completed, and a teaching platform integrating algorithm, software simulation and engineering test is built. Stimulate students' interest in active learning, mobilize their subjective initiative in learning, develop innovative thinking, and cultivate innovation and practical ability. We practice scientific research to feed teaching, transform scientific research results into teaching content, and refine the main points of the course from actual engineering and scientific research problems, which strengthens the breadth and depth of the course content. It facilitates students to establish the concept of pipe network system with a certain degree of complexity, which is both challenging and exercises students' self-learning and cooperation ability. The teaching design method of combining virtual reality and reality promotes the deep integration of modern information technology and education and teaching, continuously improves the reform of teaching quality monitoring and guarantee system, and improves the construction of practical teaching system.