Seismic resistance design of building structure has become an important course in the undergraduate stage of civil engineering. This course includes complicated theoretical contents and abstract concepts, which is difficult for visualizing the complex principles by the traditional teaching methods. In view of these problems, the operable self-made teaching aids and professional software are introduced into the course to enrich the teaching methods and help students understand it. Three knowledge points, that is, seismic response analysis of single degree of freedom system, Duhamel integral, seismic response spectrum, were taken as the case of teaching aids and professional software in this course. Based on this, the students are guided to think actively, so that the boring and difficult theory is easy to be understand. According to the feedback information of the questionnaire survey, the great teaching results are achieved by the self-made teaching aids and professional software, including the learning interest of students is stimulated, the autonomous learning ability of students is enhanced, the academic performance of students is improved and the interactive experience of classroom teaching is better, comparing with the grades that did not use it