Deepening the construction of Beijing-Tianjin-Hebei university alliance and meeting the demands of multi-agent collaborative innovation of government、industry、university and research institute are of great significance for promoting the high-quality development of higher education in the Beijing-Tianjin-Hebei Urban Agglomeration and enhancing the ability of universities to serve regional economic and social development. The Beijing-Tianjin-Hebei university alliance presents a trend of diverse levels、multi-dimensional directions and clear concepts, however, there is a gap between the construction level、construction effect and practical needs, and there are many problems in operation and management. From the perspective of multi-agent collaborative innovation and based on the demands of the service objects of the university alliance, this paper constructs a Beijing-Tianjin-Hebei university alliance model with the integration of " government、industry、university and research institute " guided by the common goal, focuses on the internal structure and operation mechanism of the university alliance, and suggests that it be guaranteed from the aspects of top-level design、management mechanism、 information platform and cultural integration.