In the current rapidly developing economic and technological environment, the field of civil and architectural engineering is faced with emerging technologies, innovative methods and cutting-edge ideas, which also brings new challenges and opportunities for education reform in the industry. However, in order to take full advantage of these opportunities and meet the challenges, we must face the reality of the current shortage of high-level interdisciplinary professionals. This situation limits the training of composite talents and the development of interdisciplinary disciplines to a considerable extent. Based on the development history and positioning changes of the relevant series of courses offered by Tsinghua University in the field of civil and architectural engineering, guided by the social needs of the new era and aiming at cultivating strong cross-disciplinary talents with comprehensive quality and ability in cross-fields, this paper discusses how to cultivate strong cross-disciplinary talents through the construction of computer-aided engineering (CAE) courses. It has formed the education concept of trinity, being a model for teachers, being diligent and teaching students according to their aptitude, adopted the teaching design driven by both scientific principles and applied practice, rebuilt the teaching syllabus and compiled high-quality textbooks, focused on cultivating students' sensitivity to frontier fields, interdisciplinary thinking and ability to adapt to changes, and emphasized the organic combination of teaching and scientific research. To realize the two-way interactive effect of scientific research promoting teaching and teaching driving scientific research, and establish a teaching team to provide interdisciplinary and cross-field teaching resources and professional guidance for cultivating strong cross-disciplinary talents. The basic experience of CAE course for civil and architectural engineering construction and reform can provide a strong guarantee for training more senior professionals with interdisciplinary background, so as to promote the civil and architectural engineering discipline to a new height in the current era of vigorous development.