In recent years, with the development and progress of the civil engineering and computer industries, the field of intelligent construction has emerged to meet the needs of industrialized construction. The major of intelligent construction is characterized by technological integration, spanning the entire life cycle of building, high automation, and energy conservation. In response to these characteristics, tailored guidance programs have been developed for graduation design teaching innovation, practice, and exploration. Compared to traditional civil engineering major, students in intelligent construction need to learn a combination of civil engineering and smart technology within limited class hours. As a result, their targeted learning depth may be lacking which leads to conceptual confusion and insufficient understanding of examples when it comes to structural design. This can make it difficult for students to start their graduation design projects. To address this issue in graduation design teaching guidance for this major, an innovative approach combining virtual simulation teaching with prefabricated building structure design and construction virtual simulation experimental teaching platforms has been proposed. Additionally, multidimensional guidance methods involving collaboration between enterprises and universities and collaborative education are utilized to help students establish systematic frameworks and clarify design processes. This further enables students to deepen their understanding of prefabricated architectural structure components as well as simulate learning experiences related to construction applications. Ultimately, this ensures efficient completion of graduation project plans. Through this teaching practical experience in graduation design project, using multi-dimensional teaching guidance integrated virtual simulation instruction methods have proven effective in promoting and guiding graduation designs focused on residential building aspects within the field of intelligent construction major. The graduation guidance based on this teaching method has achieved excellent results, and the accumulated teaching practice experience can provide a good reference for the subsequent relevant teaching and graduation design guidance.