The laboratory management is the important constituent university teaching and scientific research work. Along with the computer network technology development, informationization, the network, the modernization of the laboratory supervisory work already became the inevitable trend of development, also was one of campus digitization construction foundational work.This article unifies the university laboratory supervisory work reality, proposes two kind of structure pattern of the laboratory management synthesis information system and discusses its realization feasibility based on the network environment.The laboratory management synthesis information system should choose the management software which has the good function, the strong compatibility, simple the operation, and is easy to develop, realizes the informationization laboratory management, and leads the laboratory management quality the promotion. Laboratory management synthesis information system construction, not only may use fully had the campus net network information resource, moreover also can enhance the laboratory administrative personnel to utilize the new technology, gain the recent information skill, strengthen the laboratory administrative personnel information management ability.