In order to change the current situation that the graduation design of civil engineering majors in universities usually implement separately and lack of multi-profession collaboration，we put forward the idea of multi-profession collaborative graduation design mode of civil engineering based on engineering project. Take the methods on building multi-specialty graduation design team which covered by a project, establish the design platform, create coordination evaluation appraisal system and so on, develop the engineering consciousness on the whole project. From the implementation effect, participation enthusiasm of students is very high, scope of knowledge of students get further developed ,the ability of engineering design have improved significantly.