The goal of most newly established local universities is to training application oriented talents to serve local and regional economic construction and social development. To meet the requirement of urbanization, many newly established local universities established the civil engineering specialty. We took Bijie University as an example to discuss the course design and teaching methods of civil engineering in newly established local universities, presented an assurance system based on the main line of application oriented talent training for graduate design quality, and described specific steps of implementing the guarantee system. Practice in Bijie University achieved good results.