In order to meet the attractive requirement of practical experience and professional skills, basing on the CDIO concept, practical teaching reform of the construction cost estimation course is carried out by the way of emphasizing on the basic theories, strengthening practice steps, promoting teaching, studying, and training with competition. The reform turned out to be effective that students made considerable progress in engineering practice，especially top-notch talent bloom and win the champion of national competition a third consecutive year. The paper introduced this teaching mode.