Fluid mechanics is a basic course in science and engineering specialty. It is theoretical and difficult and contains many knowledge points, which are not easy to be understood for most students. In the construction process of excellent course of fluid mechanics, the multimedia teaching method, layered teaching mode, and heuristic teaching mode were gradually carried out in the traditional teaching practice. By introducing the CFD into fluid mechanics course teaching and combining scientific research projects with innovation practice activity, students’ knowledge was consolidated, their understanding of fluid mechanics was strengthened, and their innovative ability was improved.