Firstly, the paper expounds the basic idea of the construction of the informationalized management to scientific research in colleges and universities, then divides it into four generations according to its technical features: stand-alone version, simple online, online and the general online. The paper holds that the current informationalized management of scientific research in colleges and universities is between the second and the third generation. By analyzing the system structure of general scientific research management in colleges and universities, the paper discusses how to promote the prospectiveness and effectiveness of informational management of scientific research in colleges and universities by using the informationalized technology, and ultimately to break through the bottleneck (or group bottleneck) of the scientific research management in colleges and universities. Finally, the paper summarizes five possible trends of scientific research management system in colleges and universities.