Barrier-free design is an important content of the architecture design teaching course. For the phenomenon of professional courses in architecture, barrier-free design knowledge point spread, and not easy to form a system. The paper proposed, to construct knowledge barrier-free design and integrate the various specific professional knowledge into architecture design course teaching. Taking the training programs of architecture specialty in Southwest University of Science and Technology as an example, the paper pointed out the corresponding relationship between knowledge and curriculum, emphasized the importance of the practice and the connection between the principle of curriculum and professional ability training.