According to difficulties and problems of practical ability training of engineering students in colleges and universities in China, we carried out the exploration and practice on the college students’ practice ability training model based on students’ professional interest. The new model of students’ practical ability training was based on college students’ innovative training program and undergraduate graduation design. Students’ autonomy in the practical teaching was prominent by independent research of small experimental platform, which can cultivate engineering students’ abilities of proposing, analyzing and solving problems. The practice indicates that the new model can effectively cultivate college students’ innovative spirit and practice ability, which shows engineering talent training features and promotes the satisfaction of enterprise about the engineering graduates.