In order to meet the demand for innovative talents in establishing innovation-oriented country, we gave full advantage of comprehensive university by the effective cross between liberal arts and engineering, the equal attention on general and professional education, the practice on major and minor or double-degree system and international education, expecting the success cultivation of compound innovative talents of civil engineering. To achieve this goal, we proposed the concept of civil engineering innovative talents cultivation which contains 28 elements in four dimensions covering the knowledge structure, practical skills, ability structure and comprehensive quality. In addition, we established the talents training system that emphasized on curriculum, practice teaching, college student career planning education and teaching quality assurance with the support by the university and enterprise collaborative innovation platform. Moreover, we established the perfect operating rules for this training system. After the practice for 8 years, we achieved remarkable success. Our students had broad knowledge, high comprehensive quality, excellent innovative and practical ability as well as high-quality employment.