Engineering geology is a professional basic course to train students' ability to analyse and solve practical engineering problems with the basic knowledge of engineering geology. Taking the highway engineering geology course of civil engineering of Inner Mongolia University as an example, combining with the actual situation of teaching for many years, this paper discussed the combination between theory of teaching and professional practice and how to cultivate students' practical ability and innovation ability for non-geology majors. The paper put forward a reform model of engineering geology course for the training of applied talents in civil engineering in order to provide reference for other courses.