Guidance tactics for graduation design were presented based on engineering paradigm. Topics of graduation design should be selected by focusing on the cultivation of innovation ability, and should be combined with students' career planning, to greatly stimulate their interest of learning. Through cooperation with universities, enterprises can attract and cultivate talent, which is the key to implementing the college-enterprise joint supervision, and the training of young college teachers in enterprises is a more efficient form of cooperation. Autonomous learning is the best choice that teachers and students should make for graduation design, which is conducive to cultivating the lifelong learning ability of students.