At present, the fire resistance experiment teaching of building structure has gradually become an important teaching element of the course of civil engineering disaster prevention and mitigation. However, only a few universities in China have the physical platform of building structure fire resistance experiment. Meanwhile, due to the particularity of fire resistance experiment, the related teaching resources are very limited. Based on the modern technologies of multimedia, network communication and virtual simulation, a series of teaching resources and platforms of building structure fire resistance experiment teaching have been constructed, including physical experiment platform, virtual simulation platform, virtual teaching aids, micro experiment and MOOC. Using the platforms, the traditional experimental teaching mode is broken through. Taking interest as the core, this paper explores a virtual-actual combination teaching scheme, and the integration of experimental teaching and theoretical teaching is realized. The evaluation system of experiment teaching is established, which emphasizes both process and result, and pays attention to continuous improvement. In addition, it emphasizes the autonomy and innovation of learning, encourages students to try boldly, and enhances their subjective initiative and professional competitiveness.