By analyzing the innovation capability and talent innovation index of universities across 30 regions, this study identifies 25 key factors that university innovation capability influences on talent innovation index using bivariate correlation analysis. The 25 factors are then subjected to factor analysis, which yields three common factors: R&D resources, innovation platform construction, and innovation subjects. Multiple regression analysis is conducted to explore the significant influence of these three factors on talent innovation index. Results show that R&D resources of regional universities play a crucial role in shaping the quality of innovation talent cultivation. Based on these findings, the study proposes three recommendations: prioritize the optimization of R&D resources in regional universities, enhance the innovation platform of universities, and continuously improve innovative thinking and ability. These recommendations offer theoretical guidance for improving the quality of scientific and innovative talent cultivation in universities.